Oscillatory nature of human basal ganglia activity: Relationship to the pathophysiology of Parkinson's disease
Identifieur interne : 004019 ( Main/Exploration ); précédent : 004018; suivant : 004020Oscillatory nature of human basal ganglia activity: Relationship to the pathophysiology of Parkinson's disease
Auteurs : Peter Brown [Royaume-Uni]Source :
- Movement Disorders [ 0885-3185 ] ; 2003-04.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- Basal Ganglia (physiology), Basal Ganglia Diseases (diagnosis), Basal Ganglia Diseases (physiopathology), Basal Ganglia Diseases (surgery), Basal ganglion, Cortical Synchronization, Dopamine (physiology), Human, Humans, Nerve Net (physiopathology), Nerve Net (surgery), Oscillation, Oscillometry, Parkinson Disease (diagnosis), Parkinson Disease (physiopathology), Parkinson Disease (surgery), Parkinson disease, Parkinson's disease, Pathophysiology, Review, Synaptic Transmission (physiology), coupling, oscillations, subthalamic nucleus, globus pallidus.
- MESH :
- chemical , physiology : Dopamine.
- diagnosis : Basal Ganglia Diseases, Parkinson Disease.
- physiology : Basal Ganglia, Synaptic Transmission.
- physiopathology : Basal Ganglia Diseases, Nerve Net, Parkinson Disease.
- surgery : Basal Ganglia Diseases, Nerve Net, Parkinson Disease.
- Cortical Synchronization, Humans, Oscillometry.
Abstract
Alterations of basal ganglia physiology in parkinsonism may consist of two elements, an increase in the firing rate of neurones and a change in the pattern of synchronisation of discharges between neurones. Recent findings suggest the presence of two principal modes of synchronised activity within the human subthalamo‐pallidal‐thalamo‐cortical circuit, at <30 Hz and >60 Hz. These oscillations are dynamically and systematically modulated by task, thereby suggesting a functional role in movement. More importantly, the two frequency modes are inversely affected by movement, consistent with opposing actions, and differentially expressed according to the prevailing level of dopaminergic activity. It is argued that the balance between these modes determines the effects of basal ganglia‐thalamocortical projections on the motor areas of the cortex. The lower frequency oscillations facilitate slow idling rhythms in the motor areas of the cortex, whereas synchronisation at high frequency restores dynamic task‐related cortical ensemble activity in the gamma band.© 2002 Movement Disorder Society
Url:
DOI: 10.1002/mds.10358
Affiliations:
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Le document en format XML
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Disord.</title><idno type="ISSN">0885-3185</idno><idno type="eISSN">1531-8257</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="2003-04">2003-04</date><biblScope unit="vol">18</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="357">357</biblScope><biblScope unit="page" to="363">363</biblScope></imprint><idno type="ISSN">0885-3185</idno></series><idno type="istex">1366BB7DECA094D4F73FA07CE41B3A570BDCB0B1</idno><idno type="DOI">10.1002/mds.10358</idno><idno type="ArticleID">MDS10358</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Basal Ganglia (physiology)</term><term>Basal Ganglia Diseases (diagnosis)</term><term>Basal Ganglia Diseases (physiopathology)</term><term>Basal Ganglia Diseases (surgery)</term><term>Basal ganglion</term><term>Cortical Synchronization</term><term>Dopamine (physiology)</term><term>Human</term><term>Humans</term><term>Nerve Net (physiopathology)</term><term>Nerve Net (surgery)</term><term>Oscillation</term><term>Oscillometry</term><term>Parkinson Disease (diagnosis)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson Disease (surgery)</term><term>Parkinson disease</term><term>Parkinson's disease</term><term>Pathophysiology</term><term>Review</term><term>Synaptic Transmission (physiology)</term><term>coupling</term><term>oscillations</term><term>subthalamic nucleus, globus pallidus</term></keywords><keywords scheme="MESH" type="chemical" qualifier="physiology" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Basal Ganglia Diseases</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Basal Ganglia</term><term>Synaptic Transmission</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Basal Ganglia Diseases</term><term>Nerve Net</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="surgery" xml:lang="en"><term>Basal Ganglia Diseases</term><term>Nerve Net</term><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Cortical Synchronization</term><term>Humans</term><term>Oscillometry</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Article synthèse</term><term>Homme</term><term>Noyau gris central</term><term>Oscillation</term><term>Parkinson maladie</term><term>Physiopathologie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Homme</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Alterations of basal ganglia physiology in parkinsonism may consist of two elements, an increase in the firing rate of neurones and a change in the pattern of synchronisation of discharges between neurones. Recent findings suggest the presence of two principal modes of synchronised activity within the human subthalamo‐pallidal‐thalamo‐cortical circuit, at <30 Hz and >60 Hz. These oscillations are dynamically and systematically modulated by task, thereby suggesting a functional role in movement. More importantly, the two frequency modes are inversely affected by movement, consistent with opposing actions, and differentially expressed according to the prevailing level of dopaminergic activity. It is argued that the balance between these modes determines the effects of basal ganglia‐thalamocortical projections on the motor areas of the cortex. The lower frequency oscillations facilitate slow idling rhythms in the motor areas of the cortex, whereas synchronisation at high frequency restores dynamic task‐related cortical ensemble activity in the gamma band.© 2002 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>Royaume-Uni</li></country><region><li>Angleterre</li><li>Grand Londres</li></region><settlement><li>Londres</li></settlement></list><tree><country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Brown, Peter" sort="Brown, Peter" uniqKey="Brown P" first="Peter" last="Brown">Peter Brown</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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